Careers

Vice President, Biology at Fulcrum Therapeutics
Cambridge, MA, US

Fulcrum Therapeutics is pioneering small molecule therapeutic approaches to gene regulation in neuromuscular genetically defined diseases. The current opening is for a Vice-President of Biology with a minimum of 20 years of Pharmaceutical / Biotech experience to lead a fast-paced, innovative, Biology team.

Essential Areas of Responsibility

  • The successful candidate will play a key role shaping the future of Fulcrum Therapeutics by leading the Biology Team. The leader will be responsible for efforts to identify and enable targets through the design of robust gene and protein expression assays or identified computationally using innovative primary and iPS cell derived cell models from patients with genetically defined central nervous system (CNS) and musculoskeletal disorders. The candidate will be responsible for a talented team of creative scientists that will leverage state-of-the-art CRISPR genomic and small molecule cell-based screening in a highly automated HTS environment. This leader will need to work across an excellent multi-disciplinary team to enable targets for small molecule drug discovery and lead the team to generate decisional, statistically robust in vitro and in vivo pharmacology data to inform an innovative design chemistry team. In this leadership role, the successful candidate will be responsible for enablement of drug discovery targets with generation of intellectual property, leading discovery project team activities, presenting scientific data internally and externally, authoring study reports with regulatory documentation, contributing to high impact scientific manuscripts, identifying & managing external research collaborations, and engaging with scientific advisors and founders. In this position, this leader will be expected to work collaboratively with others across multiple disciplines while mentoring a growing team and supporting Fulcrum’s culture and core values.

Responsibilities

  • Lead the Biology team to design, execute and build quality-controlled target discovery assays and conduct in-vitro pharmacology studies using innovative human models of CNS and musculoskeletal disorders. Responsibilities include overseeing rigorous statistical analysis, data reporting, data visualization, etc.
  • Ensure execution of studies aimed at building pharmacologic relationships between drug concentration, target engagement, pharmacodynamic markers and disease protein gene expression in human cell models of neuromuscular disease.
  • Propose new programs/diseases/areas of science that could be considered for future portfolio expansion.
  • Lead team to perform target mediated mechanistic and pharmacology studies using genetic techniques including CRISPR, RNAi/shRNA, ASO, etc. in collaboration with a matrixed team of computational scientists, cell biologists, transcriptional biologists, physiologists, in vivo pharmacologists, and translational biomarker team members.
  • Coordinate with collaborators and CROs, as needed, to manage in vitro and in vivo experiments, and set clear goals and expectations for the broader team.
  • Strong written and oral communication is a requirement to support internal and external communication of data, intellectual property filings, study reports and regulatory documentation.
  • Excellent teamwork in a highly matrixed environment with ability to mentor, grow leaders and maintain focus on Fulcrum’s culture and values.
  • Member of the Fulcrum management team; participate in enterprise-wide leadership of the company

Qualifications

  • 20 years+ of drug discovery experience in pharmaceuticals/biotechnology
  • Expertise in small molecule drug discovery essential
  • Experience leading and mentoring a Biology team in a matrixed environment
  • Experience leading cross-functional teams that advanced compounds into the clinic
  • Neuroscience and muscular dystrophy expertise are preferred – ideally monogenetic disorders
  • Cell biology/screening experience preferred including patient-derived iPSC, small molecule screening, and CRISPR screening
  • Experience from target identification through support of clinical studies
  • Experience with regulatory document authoring/regulatory body interactions
  • Proven ability to develop a vision and strategy to influence key stakeholders
  • Strong external presence necessary: ability to manage CRO's, interactions with patient groups, academic partners, etc., robust publication/patent record