Biochemistry Proteomics Scientist at Cedilla Therapeutics
Cambridge, MA, US

We are looking for a biochemistry proteomics scientist

We are looking for you!

We are an energetic new company focused on harnessing intrinsic protein stability mechanisms to broaden the reach of small molecule therapeutics. By working on cancer and other diseases caused by protein dysregulation, we have an opportunity to create unique and valuable new medicines.

You are an experimental scientist with expertise in proteome analysis for diverse biological samples. As a key contributor to Cedilla’s novel proteomics platform, you will generate essential proprietary data that will facilitate the discovery, validation and prioritization of new targets and lead molecules and improve our understanding of the interactome and molecular mechanisms of action for protein targets and candidate therapeutic chemical entities. You will be empowered to design experiments and workflows and, working closely with the computational proteomics counterpart, influence decision-making and research directions.

We view you as a key leader/scientist in the company, whose contributions will be critical to the success of our endeavor. Those contributions would include:

  • Collaborating with colleagues in biochemistry, biology, and chemistry to develop proteomics strategies
  • Designing experiments to answer crucial questions about protein stability and protein-protein interactions
  • Using established or developing new computational methods to analyze various proteomics data in conjunction with computational proteomics
  • Participating in multi-disciplinary teams and helping guide protein complex optimizations
  • Managing collaborations with contract research organizations (CROs) and academic partners

Highlights of your background include:

  • Ph.D. or equivalent with 3+ years of experience with a focus on biochemistry, protein sciences or cell biology, applied to proteomics.
  • Proven track record in the implementation of diverse proteomics workflows and experiments.
  • Expertise in cell, tissue and biofluid sample preparation and manipulation to enable whole proteome analysis and affinity enrichment protein isolation (immuno- and/or chemical) for interactome mapping and selective identification of proteins from complex biological systems. Proficiency in protein biochemistry techniques (fractionation, chromatography, labeling, digestion, etc.) is required. Experience in molecular biology and with mammalian cell culture in regular and isotopically labeled media is preferred.
  • Experience in chemical proteomics applications to study small molecule-protein interactions using affinity and/or activity-based proteomic profiling both for in-lysate and whole-cell workflows. Command of automated liquid handling workstations (software and hardware) and their application to high throughput proteomics is a plus.
  • Solid understanding of quantitative high-resolution mass spectrometry (qHRMS) proteomics experimentation and its diverse, multiplexed workflows. Hands-on experience in sample processing, including optimization/miniaturization, using both peptide-labeling (e. TMT®, SILAC, etc.) and label-free experimental methods.
  • Knowledgeable in software for data acquisition and management used in proteomics research. Able to QC, analyze and interpret data generated by self and others. Good command of common visualization tools such as TIBCO Spotfire® is preferred. Hands-on experience with nLC-MS/MS instruments is preferred but this position does not require maintenance or tuning of such platform.
  • Creative and independent scientific thinking to solve complex technical and scientific problems. Capable of integrating information generated from multiple sources to shape and strengthen experimental design and research hypotheses.
  • Highly self-motivated, with excellent attention to detail and strong organizational and communication (oral and written) skills. Ability to work independently, yet team-oriented and capable of building strong relationships with peers, customers and partners/collaborators. 

You are not just an amazing biochemistry proteomics scientist, you’re the whole package!

How do I apply?

Please send your resume and anything else you would like to share to us

About Us

Cedilla is leveraging a growing understanding of the principles that dictate protein stability and applying those principles to target proteins that drive cancer and other diseases. Cedilla’s integrated product engine includes target-centric and unbiased approaches and is designed to produce small molecule therapeutics that degrade protein targets. Although degradation by small molecules has been observed serendipitously, degradation as a mechanism of action has not been pursued systematically in small molecule drug discovery.

We were launched in April 2018 and are backed by Third Rock Ventures