Senior / Principal Scientist Biomarker Development, Biology at Maze Therapeutics
South San Francisco, CA, US

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking exceptional, hands-on researchers with a strong background in disease characterization and biomarker technology to contribute to challenging projects in drug discovery and development that employ multiple therapeutic modalities to treat diseases in a variety of therapeutic areas (including neurologic disease, metabolic disease and renal disease). Our scientists work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics across Maze programs.

Your Role in Navigating The Maze:

  • You will develop the strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable data-driven decisions on program progression.
  • You will establish assays to evaluate PK/PD/efficacy relationships.
  • Initiate and manage external research collaborations to identify diagnostic and prognostic biomarkers for indications of interest.
  • You will participate in and lead cross-functional teams to support preclinical drug discovery and development.
  • Prepare, review and deliver high quality scientific presentations for internal/external use.

Your Navigation Tools:

  • PhD with at least 5 years post-degree research in an industry setting.
  • Hands on experience in the development and validation of biomarker assays in the preclinical and/or clinical setting.
  • Extensive experience with diverse biomarker assay technology platforms and proven assay troubleshooting skills.
  • Strong publication record and demonstrated experience conducting independent research.
  • Strong leadership skills and evidence of strategic scientific thinking.
  • Effective managerial skills and the ability to lead independent scientists with different backgrounds.