Scientist, Biology at Rheos Medicines
Cambridge, MA, US

The Role

Responsible for initiating, designing and developing new scientific projects relevant to different immune related diseases. Ability to also perform a variety of immune based in vitro assays including both cellular and molecular biology techniques. Familiar with in vivo murine models of immune related diseases and capable of in vivo model development as well as immunometabolic techniques such as Seahorse Bioflux analyses.


Major Responsibilities


  • Responsible for developing both in vivo mouse models as well as in vitro immunological assays in the relevant immune diseases
  • Support scientists in developing new assays for example; setting up of mixed lymphocyte reactions, Treg suppression assays, in vitro cytotoxicity assays and projects
  • Independently design, execute studies and perform data analyses
  • Partner with bioinformatics and metabolism scientists to analyze and interpret data to generate novel hypothesis and validate targets for modulation of immune cell functions
  • Establish novel technologies and platforms for interrogating immune cells in human patient tissues
  • Participate in drug-discovery efforts including developing novel assays for compound screening or biomarker identification
  • Test and implement cutting edge technologies such as Seahorse Bioflux analyses to drug new targets




Requirements and Qualifications:


Education and Training:

Bachelors in Cellular and Molecular Immunology, cancer biology or Biochemistry with 5-8 years OR MS with 2-5 years’ relevant and extensive experience in immunology research and development in the Biotech industry


Required Experience:

  • Extensive experience in invitro immune based assays in isolating, differentiating, culturing and profiling immune cell subsets of both innate and adaptive immunity or various other non-immune cell types.
  • Experience with in vivo mouse models of immune related diseases such as autoimmunity and tumor immunology
  • Hands-on experience with mouse/human immunology strongly preferred 
  • Prior experience or track record in Immunometabolism a huge plus


Knowledge, Skills & Abilities:

  • Ability to design and develop independent projects
  • Ability to be creative and apply a wide variety of scientific concepts and innovate and solve problems
  • Versatile experience with various mouse models
  • Relevant industry experience and working with matrixed project teams
  • Design and execution of methods to support platform and program development including assays for characterizing target expression / engagement
  • Ability to prepare technical reports to support process development/IND filing