Rheos Medicines is a biopharmaceutical company discovering and developing novel medicines that target immune cell metabolism to treat patients with a broad range of severe diseases, including those with autoimmune disease and cancer. We are rapidly advancing a first-infield approach in immunometabolism by applying a comprehensive, systems-biology understanding of the metabolic pathways that drive immune cell function. Launched in 2018 by Third Rock Ventures, Rheos is built on groundbreaking science and currently has a team of more than 30 employees advancing our pipeline of immunometabolism drugs.
Rheos is seeking an exceptional scientist who can comfortably operate at the interface between technology and biology. The successful candidate will have the opportunity play a central, hands-on role in the development and execution of mass spec-based metabolic analyses of primary human immune cells, patient isolates, and samples obtained from in vivo models.
- Develop and use novel methodologies at the interface of technology and biology. Activities may include optimization of sample prep strategies, implementation of emerging technologies like imaging MS, and/or in vivo tracing studies.
- Analyze, compile, and communicate the results of studies on a regular basis in project team meetings.
- Productively communicate the value of new methods and results within the company, interact with peers in the cellular metabolism group, and as a collaborator with both immunology and drug discovery teams.
- External communication at scientific conferences and meetings is expected.
Requirements and Qualifications:
- PhD in Biochemistry, Analytical Chemistry, Cell Biology, Chemical Biology or a closely related field, such as Chemical Engineering.
- A PhD and a minimum of 5-8 years postdoc or preferably industry experience
- Strong track record in the development of novel, technologically advanced methodologies and assays, and their implementation to gain new biological insights
- Experience in mass spec instrumentation as it relates to metabolomics, lipidomics, and associated data analysis
- Experience with cell culture methods and stable isotope tracing is desirable
- Mass spec data processing, analysis, and organizational capabilities are central to the position; beyond operation of commercial mass spec software, this will include extensive use of Microsoft Excel, as well as in-house proprietary software packages
Knowledge, Skills & Abilities:
- Strong written and verbal communication skills are essential
- Ability to function successfully in a cross functional, matrix-based research organization
- Desirable skill-sets include familiarity with various mass spec software packages and analytic techniques with QToF and Q-Exactive instrumentation
- Strong knowledge of central metabolism, and/or immunology and signaling are valuable assets for this position