Careers

Associate Director/ Director, Toxicology at Relay Therapeutics
Cambridge, MA, US
Relay Therapeutics is a new breed of company at the intersection of computation and biotechnology that is committed to creating medicines that will have a transformative impact on patients. 
 
We combine unprecedented computational power with leading-edge experimental approaches across the fields of structural biology, biophysics, chemistry and biology. This integration illuminates – for the first time – the full mobility of a protein and provides key insights into how the dynamic nature of a protein’s conformation regulates function. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients’ lives. We don't just stare hard problems in the face. We go out looking for them. Are you energized by attempting to do the impossible? We're looking for you.
 
At Relay, our team is driven by the ultimate collaboration across each of our drug discovery disciplines.  Putting protein motion at the heart of drug discovery is a challenge, but we are confident that our team’s dedication and urgency will create opportunities that deeply impact the lives of the patients.  Our initial programs are focused on developing therapeutics in oncology.
 
Relay Therapeutics is a private company launched in 2016 with financing from Third Rock Ventures and an affiliate of D. E. Shaw Research.  To date the company has raised $520M from investors including Third Rock Ventures, SoftBank Vision Fund, GV, Casdin Capital, BVF Partners, EcoR1 Capital, Foresite Capital, Perceptive Advisors, Tavistock Group and an affiliate of D.E. Shaw Research.
 
 
The opportunity
Are you a seasoned and versatile Toxicologist who looks to have tangible impact on small molecule drug development?  Then we’re looking for you!  You will play an active role on cross‐functional program teams and represent pre-clinical safety for multiple discovery and development stage projects.  As the domain expert, you will bring ability to partner with other existing disciplines within the company, such as DMPK, biology, chemistry, program management as well as the emerging functions, such as regulatory affairs, clinical research, quality assurance, and manufacturing. You will collaborate internally as well with external pre-clinical CROs on toxicology issues during in vivo candidate evaluation.  You have seen successful drug discovery and development first hand and have prior experience with IND/NDA filings.  Come to Relay and do the best work of your career yet!
 

Your role

      • You’ll play a leading role in nonclinical study design and protocol development for toxicology, toxicokinetic, and safety pharmacology studies for small molecule drug candidates.
      • You’ll be accountable for reproductive and developmental safety, safety pharmacology and toxicology study design, dosage selection, study initiation as well as monitoring, data review, and reporting.
      • You’ll design, implement, analyze, and interpret studies conducted at Contract Research Organizations (CROs) to assess mechanisms of toxicity.
      • You’ll apply your experience of partnering with and managing multiple CROs to ensure they resource and prioritize Relay-sponsored studies appropriately and deliver on internal projects timelines and milestones.  
      • You’ll maintain a robust network of CRO and consultant relationships to ensure scalable, flexible support capacity to respond to program needs at all stages of development.
      • You’ll review and evaluate toxicology findings from in vivo efficacy studies carried out by research collaborators.
      • You’ll maintain up-to-date Toxicology plans (linked to overall drug development plan and TPP) for all projects/programs/products.
      • You’ll author and review regulatory documents, participate in interactions with regulatory agencies, and work collaboratively with various multi-disciplinary project teams.
 

Your background

    • You have earned DVM or PhD in toxicology, pathology, pharmacology, immunology and/or other relevant scientific discipline.
    • Are you Board certified in toxicology or pathology? That’s a great plus, not a must.
    • You know what successful small drug development looks like.  You bring 10+ years of biotech/pharmaceutical industry experience in preclinical safety evaluation.  
    • You are well versed in designing, conducting, and monitoring safety pharmacology/toxicology studies.
    • You have a track record of developing strong partnerships with contract research labs and managing them for success and accountability.
    • You have a reputation for being an effective project team member and collaborating across disciplines to move programs forward. 
    • You know relevant FDA and ICH guidance’s and GLP requirements inside and out.
    • You are a clear, candid, and concise communicator – whether in person, by phone/ email, or in front of an audience presenting.
    • You are passionate about toxicology are able to share insights and guidance with others across disciplines.
At Relay, we believe that along with our people, our culture is our greatest asset.  In fact we're proud to share we were named as one of the Boston Business Journal's "Best Places to Work" in 2017 & the #1 place for small companies in 2018.   To drive that culture, no one will stop you or hold you back. Instead, we will give you the tools and colleagues to push forward relentlessly and cheer you on as you go. If this resonates with you, drop us a line.
 
Relay Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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