Scientist/Senior Scientist, Medicinal Chemistry at Pliant Therapeutics
Redwood City, CA, US
Pliant Therapeutics is an early stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar for progress to meet unmet medical needs for patients and physicians. The company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company is seeking passionate, creative and dedicated scientists to join our team and contribute to our mission.

Position Overview

Pliant is seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry team in the pursuit of novel small molecules to treat fibrotic disease. The successful candidate will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy.


Plan and execute the synthesis, purification, and characterization of complex small molecules.

Integrate and utilize modern medicinal chemistry principles and tools, including structure based drug design.

Advance drug discovery programs by interacting with other chemists, biologists and external collaborators to understand and optimize DMPK and in vitro and in vivo pharmacological properties.

Contribute effectively to patent, report and scientific publication writing.

Execute inventive contributions towards new chemical target structures, and employ sound judgment in the evaluation and strategic decision making around early screening or literature hits.

May have the opportunity to manage one or more Research Associates.

Desired Skills and Experience:

PhD. in synthetic organic chemistry or equivalent.

Structure-based drug design experience preferred.

At least 3-10 years industry experience strongly preferred.

High level of creativity and productivity with strong synthetic problem solving skills.

Excellent scientific expertise in organic synthesis, conversant with the current literature.

Ability to champion the chemistry efforts into new directions to achieve project milestones.

Strong evidence of conceptual thinking, active follow through and vigorous scientific curiosity.

Proven ability to work well with others in a dynamic and highly collaborative environment.

Exceptional interpersonal, verbal and written communication skills

Note to Staffing and Placement Firms:

If you are interested in submitting potential candidates for our open positions, we ask that you refrain from contacting Pliant employees directly, but rather request that you email your firm’s information to We will be happy to review your information and will contact you if a need arises to utilize your services.

Please note that all of our open positions are managed through our Human Resources department, and unsolicited resumes in advance of an agreement in place will not be accepted. Resumes sent directly to Pliant employees or our consultants will also not be accepted as referrals. Thanks in advance. We look forward to a potential collaboration as we continue to grow the Pliant team.