Senior Scientist II/Associate Director, Safety Pharmacology and Toxicology at Revolution Medicines
Redwood City, CA, US
REVOLUTION Medicines is an exciting, early stage biotechnology company that discovers and develops innovative drugs for cancer patients directed toward frontier oncology and immune-oncology targets. The company draws inspiration from evolution and natural products that are inherently rich with biological function. REVOLUTION Medicines deploys an innovative toolkit including REVBLOCKS™, an integrated suite of rapid, agile, and modular synthesis methodologies applied to simple chemical “building blocks,” and the REVEAL™ computational platform, which uses evolution’s lessons to inform selection of chemical scaffolds guide drug design for non-classical drug targets. As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.

The Opportunity:

As the lead for Safety Pharmacology and Toxicology, you will oversee the non-clinical safety pharmacology and toxicology for the Company’s programs at the discovery and preclinical development stage, as well as in to early stage clinical development. Specifically, you will:

Be a critical member of the leadership of the emergent Development Sciences organization.

Be a key member of the multi-disciplinary research project teams.

Be accountable to the Head of Development Sciences, and the Research and Development Team Leads for performing cutting-edge science to understand the potential and observed toxicities of our molecules, and model these in preclinical settings.

Independently design and execute experimental strategies using cellular and molecular immunological techniques to investigate drug and target-related toxicities and mechanisms of action.

Manage, analyze and archive experimental data, and present experimental results at internal meetings and scientific conferences.

Be accountable for the oversight of key CROs.

Be accountable for the preparation of documents for regulatory filings and interactions with partners and collaborators.

Establish collaborations with leading academic research groups.

Be accountable for toxicology input to the Research and Development governance structure.

Required Experience, Skills, and Education:

Ph.D. degree or equivalent in cancer biology, cell biology or a related discipline, with at least three years of relevant industry experience in toxicology for Senior Scientist level or five years for Associate Director level.

Demonstrable record of strong leadership and teamwork.

Strong track record of research productivity as evidenced by high-quality, impactful publications, preferably in the field of cancer biology or related field.

Experience of managing CROs.

Extensive hands on experience in relevant laboratory techniques.

Rigorous, quantitative and detail-oriented experimentalist.

Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high energy environment.

Excellent written and verbal communication skills.

Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.