Senior Scientist, Analytical Chemistry at Neon Therapeutics
Cambridge, MA, US
Position Summary

Neon is seeking a highly-motivated Senior Scientist to join the analytical chemistry group. The candidate will work within the analytical group and in close collaboration with peptide synthesis and other groups at Neon on programs that aim to develop novel personalized neoantigen based cancer vaccines. He/she will work independently as well as part of a multi-disciplinary research team to develop high throughput purification processes for the manufacturing of neoantigen cancer vaccines.

Job responsibilities include:

Develop high throughput peptide purification process for the manufacturing of neoantigen cancer vaccines
Develop analytical methods such as UPLC for the analysis of peptides
Optimize sample loading, column, gradient and other parameters to achieve the most efficient purification of peptides
Develop automation capability for the purification process
Perform peptide purification using LC-MS systems and develop fraction pooling strategies
Analyze peptide samples using UPLC, MS, and other techniques
Maintain analytical and purification instruments
Write technical reports and study summaries
Work productively in a team environment and independently and deliver against timelines.
Experience and essential skills:

A Ph.D. with more than 5 years of industry experience in the purification method development of pharmaceuticals
Comprehensive knowledge and technical expertise in chromatographic separation and HPLC analysis
Strong experience in mass-directed purification with automated LC-MS systems
Hands on experience in HPLC trouble shooting and maintenance
Experience with UPLC-MS systems
Experience in using Masslynx and Empower software
GMP process development experience is highly desirable
Excellent interpersonal and communication skills and a pro-active mentality
Highly organized with strong attention to details
Must be able to work in a team and collaborative environment