Medicinal Chemistry Principal Scientist at Tango Therapeutics
Cambridge, MA, US
Position Summary:

The successful candidate will:

Be responsible for the design and execution of medicinal chemistry programs that lead to the identification of drug candidates for clinical development

Integrate aspects of the entire drug R&D process, with emphasis on hit finding through lead optimization, ADME/PK, pharmacology and toxicology

Prioritize medicinal chemistry plans and manage external chemists and collaborations to deliver small molecule development candidates on aggressive time lines

Actively follow and integrate scientific advancements and literature within the area of research interest

Job Responsibilities:

PhD in Organic Chemistry and 7 years of relevant pharmaceutical industry experience, with demonstrated success in lead optimization programs

In-depth knowledge of the entire drug discovery process, with expertise and demonstrated strong skills in medicinal chemistry drug design and discovery

Experience functioning within a strong multi-disciplinary team and utilizing physicochemical, biochemical, ADME/PK, and pharmacological data to drive medicinal chemistry strategies is required

Success in applying modern and emerging methodologies and technologies to the synthesis of small molecule drug candidates

Strong organizational and communication skills within a matrix driven organization

Prior experience acting as project or chemistry team lead preferred

A record of success toward clinical candidates is essential

Experience in managing external FTE resources in chemistry to high levels of performance is favorably considered