Scientist/Senior Scientist, Immunology at Magenta Therapeutics
Cambridge, MA, US
About the Company

Magenta Therapeutics is a biotechnology company harnessing the power of stem cell science to revolutionize stem cell transplantation for patients with immune and blood-based diseases. By creating a platform focused on critical areas of transplant medicine, Magenta Therapeutics is pioneering an integrated approach to stem cell therapies to create patient benefits. Founded by internationally recognized leaders in stem cell transplant medicine, Magenta Therapeutics was launched in 2016 by Third Rock Ventures and Atlas Venture and is headquartered in Cambridge, Mass. For more information, please visit

Position Overview

The successful candidate will be an integral member of a team developing novel therapeutics to transform hematopoietic stem cell transplantation science. This challenging opportunity requires in depth knowledge of auto-immunity, T cell biology and graft vs host disease. The role will help identify new strategies to modulate the immune system prior to autologous and allogeneic hematopoietic stem cell transplant for the treatment of autoimmunity and cancer. This approach provides a unique opportunity to gain insights into the disease mechanisms while also evaluating the safety and efficacy of novel therapies. The role will rapidly progress these strategies from in vitro assays and mouse models to large animals and humans.

Primary Responsibilities:

Perform in vitro and in vivo immunological assays to help broaden our understanding of how our therapeutic leads can affect normal immune function and autoimmune disease

Collaborate with the broader scientific team to design and execute experiments aimed at defining the pharmacokinetics, pharmacodynamics and safety of our lead candidates in immune-competent mice and humanized mouse models

Develop mouse autoimmune disease models to test the activity of therapeutic leads

Engage colleagues in cross-disciplinary scientific discussion, present scientific data to internal and external audiences and stay abreast of relevant scientific literature


Ph.D. with a strong background in immunology or similar field.

Extensive experience with human and mouse in vitro cellular techniques including functional assays (proliferation, activation, intracellular staining and cytokine profiling).

Experience in cell separation techniques (bead separation and density centrifugation)

Knowledge of mouse and human hematopoiesis, including hematopoietic stem cell transplant, is highly desirable.

Hands on experience analyzing complex immunophenotypes by flow cytometry.

Understanding of current research in T cell depletion and selective depletion/inhibition of alloreactive T cells.

Experience using in vivo models of auto-immunity or graft versus host disease required.

A strong track record of success as demonstrated by high impact publications and project leadership is highly preferred.

The ideal candidate will be creative, rigorous, goal oriented and prepared to be immersed in a fast-paced and innovative environment that offers the opportunity to work and publish.

Excellent written and verbal communication skills and the ability to work effectively in a multi-disciplinary team are required.

We offer competitive compensation along with a comprehensive benefits package. To apply, please submit your resume and include the job title in the subject of your email.