Scientist II, Protein Sciences at Nurix
San Francisco, CA, US
We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide scientific leadership in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts. This person will play a key role in the implementation of higher throughput methodologies to expand protein sciences capabilities. This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Ph.D. in Biochemistry, Cell and Molecular Biology, or related field with 3+ years post-degree industry experience
Expertise in construct design, protein expression & purification, and protein characterization pertinent to small molecule drug discovery
Experience with protein production including multiprotein complexes in bacterial, baculovirus and mammalian expression systems
Knowledge of expression platforms, purification systems and analytical techniques (e.g. Wave bioreactor, AKTA, HPLC/MS, TFF)
Familiarity with the development of higher throughput methodologies and automated technologies for protein purification
A strong track record (publications, industry experience) with excellent interpersonal skills and ability to work in a team environment
The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach
The candidate should be enthusiastic, driven, have the ability to work independently and thrive in a dynamic start-up environment.
Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.
Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. In September 2015, Nurix entered into an exclusive collaboration with Celgene for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology.
Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California