Careers

Principal/Senior Scientist, Pharmacology and Translational Research at Goldfinch Bio
Cambridge, MA, US
The Opportunity

We’re seeking a highly motivated and technically excellent Principal Scientist with a strong background in pharmacology and translational research to join our Pharmacology and Nonclinical Development Department to contribute to building our discovery pipeline for renal diseases. The successful candidate will focus on the development of in vitro and in vivo pharmacology models and on the identification of novel biomarkers to advance the Goldfinch Bio pipeline. Responsibilities include setting up the pharmacology infrastructure, strategy and vision for kidney diseases to help advance the Goldfinch Bio pipeline.

Major Responsibilities

Develop in vitro assays and implement in vivo models to evaluate the PK/PD and efficacy of pipeline compounds. PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects.
Develop strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression.
Implement the strategy by establishing and managing external research collaborations.
Write protocols, evaluate and analyze data, write reports and present data-driven recommendations to project teams to enable scientific driven go/no go decisions for programs.
Participate in and lead cross-functional teams to support preclinical drug discovery and development.
Prepare, review and deliver high quality scientific presentations for internal/external use.
Commitment to help the team achieve deliverables and meet aggressive timelines.
Keep abreast of innovative technologies and their relevance with the aim of bringing therapies to patients faster or more efficiently.
Requirements and Qualifications

EDUCATION
PhD in Pharmacology, Biochemistry or related field.
REQUIRED EXPERIENCE
Minimum of 8 years post-degree research in an industry setting.
Strong publication record.
Extensive experience in cellular and biochemical science such as standard molecular biology and protein biochemistry techniques and/or mass spectrometry technologies for biomarker identification is required.
Demonstrated ability to integrate pharmacology concepts.
Experience managing CROs.
Excellent communication and interpersonal skills, and proven success working in matrix environments.
Experience with regulatory submissions of orphan drugs is a plus.
KNOWLEDGE SKILLS AND ABILITIES
Hands on experience in the development and validation of biomarker assays in the preclinical and clinical setting required.
Strong leadership and evidence of strategic scientific thinking.
Effective managerial skills and the ability to lead independent scientists with different skill sets.
Expertise in cutting edge assay technologies and proven assay troubleshooting skills.