Principal Scientist, Biomarker and Translational Research at Goldfinch Bio
Cambridge, MA, US
The Role

We’re seeking a highly motivated Principal Scientist with a strong background in disease characterization and biomarker technology to join our Pharmacology and Translational Science Department to contribute to building our pipeline for renal diseases. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics for Goldfinch programs. Responsibilities include leading scientific research to identify, evaluate, and characterize relevant blood, urine, and kidney biomarkers that will provide useful pharmacodynamic and efficacy endpoints in preclinical and clinical settings.

Major Responsibilities

Develop strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression.
Develop in vitro and biochemical assays to evaluate efficacy, PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects.
Lead the identification and validation of novel biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression.
Establish and manage external research collaborations to identify diagnostic and prognostic biomarkers for indications of interest in chronic kidney disease.
Participate in and lead cross-functional teams to support preclinical drug discovery and development.
Prepare, review and deliver high quality scientific presentations for internal/external use.
Commitment to help the team achieve deliverables and meet aggressive timelines.
Requirements and Qualifications

PhD with at least 6 years post-degree research in an industry setting.
Extensive hands-on experience with biomarker technology platforms, including untargeted and targeted mass spectrometry, ELISA, etc.
Hands-on experience in cellular and biochemical science such as standard molecular biology and protein biochemistry techniques.
Hands on experience in the development and validation of biomarker assays in the preclinical and clinical setting required.
Strong publication record and demonstrated experience conducting independent research, preferably in the field of monogenic diseases
Strong leadership and evidence of strategic scientific thinking.
Effective managerial skills and the ability to lead independent scientists with different skill sets.
Expertise in cutting edge assay technologies and proven assay troubleshooting skills.

If you would like to be considered for an opportunity at Goldfinch Bio, please submit your CV with the title of the position in the subject line.