Associate Scientist, Discovery Biology at Tango Therapeutics
Cambridge, MA, US
Position Summary:

Tango, a 2017 “Fierce 15” company, is an exciting new oncology company launched by Third Rock Ventures, one of Boston’s premier biotech funding groups. Our focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We invert the traditional discovery paradigm by putting patient selection before target identification. We use deep DNA sequencing and CRISPR-based screening to identify novel targets for specific subgroups of cancer patients. Our goal is to leverage the principles of synthetic lethality to find novel weaknesses in cancer cells and use them to provide a roadmap to cures. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments; thereby enabling greater speed, success, and impact for those patients.

We are seeking a motivated and scientifically rigorous associate scientist to perform laboratory-based research in a collaborative, multidisciplinary team environment. The successful candidate will have experience in biological target validation, utilizing genetic and pharmacological perturbants in mammalian cell culture to discover and confirm candidates for novel therapeutics. As a member of the Discovery Biology group, you will also be involved in mechanism-of-action studies, the interpretation and presentation of data, and will function as an integral member of the team to advance novel cancer therapeutic targets.

Job Responsibilities:

Design and optimize existing and new protocols

Conduct mammalian cell culture-mediated genetic perturbation studies using RNAi and/or CRISPR, as well as pharmacological perturbation studies to validate biological targets

Perform mechanism-of-action studies, including analysis of gene expression, pathway expression, protein levels, and or/or target activity levels, to validate and advance targets

Perform cellular assays to support drug discovery efforts

Communicate and engage with contract research organizations

Independently summarize, analyze and present your work to project and senior leadership teams; document the data using ELN


BS/MS in Molecular or Cell Biology, or related field, with a minimum of four years relevant industry experience, or equivalent academic experience

Expertise with genetic perturbation (e.g. CRISPR and/or RNAi) and genetic rescue techniques required

Expertise with mammalian cell culture techniques required

Experience with protein detection methods (e.g. Western immunoblot and ELISA) required

Isolation and manipulation of RNA and DNA required

Cloning experience a plus

Flow cytometry and FACS experience is favorably considered

Ability to work in a cross-functional team environment and a flexible team-oriented perspective is essential

Strong attention to detail and the ability to multi-task required

Strong verbal and written communications skills required

Knowledge of cancer biology pathways is favorably considered


If you are interested in joining the Tango team, please submit your CV with the title of the position in the subject line.