Research Associate, Target Identification at Tango Therapeutics
Cambridge, MA, US
Position Summary:

Tango, a 2017 “Fierce 15” company, is an exciting new oncology company launched by Third Rock Ventures, one of Boston’s premier biotech funding groups. Our focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We invert the traditional discovery paradigm by putting patient selection before target identification. We use deep DNA sequencing and CRISPR-based screening to identify novel targets for specific subgroups of cancer patients. Our goal is to leverage the principles of synthetic lethality to find novel weaknesses in cancer cells and use them to provide a roadmap to cures. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments; thereby enabling greater speed, success, and impact for those patients.

We are seeking a motivated, self-starter to perform laboratory-based research in a collaborative, multidisciplinary team environment. The successful candidate will have experience in Molecular Biology, cell culture, and CRISPR technologies. You will interact closely with Scientists and other RAs in Oncology target discovery and validation using cutting edge functional genomics screening technologies and molecular biology tools.

Job Responsibilities:

Perform large-scale CRISPR screens
Construct CRISPR gRNA libraries and individual gRNA clones
Cas9 cell line engineering
Coordinate with other functional groups to plan and execute high-throughput workflows
Compile and analyze data to support/contribute to technical reports and publications

B.S. or M.S. degree in Genetics, Molecular Biology, Biochemistry, Bioengineering, or Cell Biology
Experience working with CRISPR and/or shRNA technologies
Strong Molecular Biology skills
Experience working with lentiviral vectors
Experience with Oncology therapeutic target discovery and validation
Hands on experience with FACS, Taqman RT-qPCR as well as preparation of NGS libraries
Experience with small molecule target identification and validation
Familiarity with common sequence data analysis software packages
Strong organizational skills and attention to detail
Excellent written and verbal communication skills

If you are interested in joining the Tango team, please submit your CV with the title of the position in the subject line.