Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. The Company utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines. Neon Therapeutics’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute. NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer. Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.
Neon Therapeutics was incubated and launched by Third Rock Ventures, and raised a $55M Series A in 2015 and more recently a $70M Series B in December 2016 and $36M follow-on in December 2017.
Neon is seeking a highly skilled and motivated immunologist ready to work in an enthusiastic and collaborative environment. The successful candidate will work across multiple programs and s/he will be developing pre-clinical in vivo and in vitro assays to help advance Neon’s vaccine pipeline. The candidate will work hands-on in lab using cellular assays to measure immunogenicity of vaccine candidates using various mouse tumor models. The candidate will also be responsible for analyzing and presenting data to cross-functional teams in a timely manner.
Isolation of leukocytes, CD4+T and CD8+Tcells from murine lymphoid organs
Perform and analyze ex vivo immune cell assays such as ELISpot, cell sorting, flow cytometry, MSD, ELISA and related immune assays
Analysis of multicolor flow cytometry data
Grow and maintain cell lines and primary cell cultures
Design mouse immunogenicity and tumor efficacy experiments
Maintain an up to date and well-organized electronic lab notebook
Responsible for general laboratory assistance including lab equipment and inventory maintenance, ordering and receiving reagents
Analyze and communicate data to other team members and department leads
Experience and essential skills
S., B.A., or M.S. degree in Biology or relevant field
Minimum of 2 years of technical experience in immunology/ oncology or related field
Strong background on immunology, oncology, biochemistry and/or biotechnology
General immunology techniques, including T cell-based assays
Ability to identify, troubleshoot and solve critical issues associated with immunological methods
Ability to work and communicate in a large cross-functional team
Excellent attention to detail
Proven track record of being personable, energetic, accountable, and an effective communicator
Must work well independently and as an integral part of the team
If you are ready for the next step in your career and want to work on cutting-edge science in a dynamic, fun environment, please explore our open positions. To apply, please send your resume. In the subject line please note the position for which you are applying.