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Research Associate, Cancer Immunology at Neon Therapeutics
Cambridge, MA, US

Company Summary

 

Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. The Company utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines.  Neon Therapeutics’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute.  NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer.  Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.

 

Neon Therapeutics was incubated and launched by Third Rock Ventures, and raised a $55M Series A in 2015 and more recently a $70M Series B in December 2016 and $36M follow-on in December 2017.

 

Position Summary

 

Neon is seeking a highly skilled and motivated immunologist ready to work in an enthusiastic and collaborative environment. The highly-motivated Research Associate will work on developing cancer immunotherapeutic technology against neoantigen targets that are shared across patients. S/he will need to work effectively on a team while also independently perform cell and molecular biology assays. The candidate will work closely with the departments of T cell immunology, molecular immunology, peptide chemistry, and bioinformatics.

Job responsibilities

 

Perform cell culture of multiple mammalian cells including both adherent and suspension cell lines

Production of stable cell lines using transfection or transduction

Analysis of multicolor flow cytometry data

Molecular cloning and RNA/DNA isolation

Analysis and presentation of results to larger scientific groups

Work productively in a team environment and independently to deliver against timelines

Keep very well documented electronic lab notebook

Experience and essential skills

 

S., B.A., or M.S. degree in biology or relevant field

Minimum of 1 year of technical experience in cell culture and molecular biology lab

Strong background in immunology, cell biology, biochemistry and/or biotechnology

Demonstrated mastery of mammalian cell culture techniques and stable transfection

Strong analytical expression methods, including western blotting and flow cytometry

General molecular biology techniques, including bacterial culture and plasmid preparation

Ability to work and communicate in a large cross-functional team

Excellent attention to detail

Ability to maintain inventories of equipment, supplies, and related research materials

Excellent organizational and record-keeping skills

Strong written and oral communication skills

Independent, flexible, self-motivated

 

 

If you are ready for the next step in your career and want to work on cutting-edge science in a dynamic, fun environment, please explore our open positions. To apply, please send your resume. In the subject line please note the position for which you are applying.