Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. The Company utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines. Neon Therapeutics’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute. NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer. Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.
Neon Therapeutics was incubated and launched by Third Rock Ventures, and raised a $55M Series A in 2015 and more recently a $70M Series B in December 2016 and $36M follow-on in December 2017.
Neon is seeking a highly skilled and motivated immunologist ready to work in an enthusiastic and collaborative environment. The highly-motivated Research Associate will work on developing cancer immunotherapeutic technology against neoantigen targets that are shared across patients. S/he will need to work effectively on a team while also independently perform cell and molecular biology assays. The candidate will work closely with the departments of T cell immunology, molecular immunology, peptide chemistry, and bioinformatics.
Perform cell culture of multiple mammalian cells including both adherent and suspension cell lines
Production of stable cell lines using transfection or transduction
Analysis of multicolor flow cytometry data
Molecular cloning and RNA/DNA isolation
Analysis and presentation of results to larger scientific groups
Work productively in a team environment and independently to deliver against timelines
Keep very well documented electronic lab notebook
Experience and essential skills
S., B.A., or M.S. degree in biology or relevant field
Minimum of 1 year of technical experience in cell culture and molecular biology lab
Strong background in immunology, cell biology, biochemistry and/or biotechnology
Demonstrated mastery of mammalian cell culture techniques and stable transfection
Strong analytical expression methods, including western blotting and flow cytometry
General molecular biology techniques, including bacterial culture and plasmid preparation
Ability to work and communicate in a large cross-functional team
Excellent attention to detail
Ability to maintain inventories of equipment, supplies, and related research materials
Excellent organizational and record-keeping skills
Strong written and oral communication skills
Independent, flexible, self-motivated
If you are ready for the next step in your career and want to work on cutting-edge science in a dynamic, fun environment, please explore our open positions. To apply, please send your resume. In the subject line please note the position for which you are applying.