Tango, a 2017 “Fierce 15” company, is an exciting new oncology company launched by Third Rock Ventures, one of Boston’s premier biotech funding groups. Our focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.
Our discovery efforts begin and end with patients. We invert the traditional discovery paradigm by putting patient selection before target identification. We use deep DNA sequencing and CRISPR-based screening to identify novel targets for specific subgroups of cancer patients. Our goal is to leverage the principles of synthetic lethality to find novel weaknesses in cancer cells and use them to provide a roadmap to cures. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments; thereby enabling greater speed, success, and impact for those patients.
We are seeking a biochemist/enzymologist to work on these exciting new targets, as an integral member of the biochemistry group across multiple programs. The successful candidate will have experience in drug discovery characterizing enzymes and protein targets, setting up microtiter plate assays and determining the affinity of inhibitors to guide structure activity relationships. An appreciation of kinetics and thermodynamics, and the flexibility to work on multiple targets is important for this position.
- Perform laboratory-based research in a collaborative multidisciplinary team environment under minimal supervision
- Develop microtiter plate-based biochemical assays for screening, identification and characterization of drug-like small molecule ligands and inhibitors of protein drug targets
- Optimize existing assay protocols and apply routine assays for quality control of protein constructs
- Communicate and engage with contract research organizations
- Operate and maintain laboratory equipment such as multimodal microplate readers
- Independently summarize, analyze and present your work to project and senior leadership teams; document the data using ELN
- Deep understanding of enzymology and enzyme kinetics
- BS/MS in Biochemistry or related field with a minimum of five years relevant industry experience
- Understanding of how to scale up and troubleshoot assays is required; experience working with CROs strongly preferred
- Experience with HTS a decided asset
- Familiarity with fluorescence spectroscopy including FRET and FP assays
- Familiarity with radiolabeled assays, including filter binding
- Cloning, expression and purification experience a plus
- Ability to work in a cross-functional team environment and a flexible team-oriented perspective is essential
- Strong attention to detail and the ability to multi-task required
- Strong verbal and written communications skills required
- Knowledge of cancer biology pathways is favorably considered
- Candidates who are keen experimentalist, enthusiastic, creative and have a passion for drug discovery are encouraged to apply!