Cambridge, MA, US

Position Summary

Neon is seeking a highly-motivated Associate Scientist (Histology) to join Neon’s Immune monitoring group. The candidate will work within the Immune monitoring group in close collaboration with other scientists in the group and with other groups at Neon. The group is focused on translational immunology and he/she will work directly with the clinical samples generated during Neon Trials. The role is primarily responsible for all aspects of histology in the group, from processing fresh tissue through creating reports that outline, summarize and interpret results. He/she will work independently as well as part of a multi-disciplinary research team to develop different immuno- histochemical assays.

Job responsibilities include:

  • Responsible for building the pathology lab at Neon.
  • Develop, validate and execute multiplex Immuno-fluorescence assays for characterizing the expression, distribution and localization of markers in normal and tumor tissues including but not limited to immune cells
  • Develop multiplex IHC analysis to evaluate multiple biomarkers for T cell and macrophage cells on human tumor samples.
  • Manage CROs and external collaborators.
  • Maintain tissue inventory and sample logs.
  • Develop SOPS and maintain a high standard of experimentation and record keeping
  • Will be an active player in clinical sample management and analysis.
  • Improvement of current processes and implementation of new technologies.
  • Analysis and presentation of results to larger scientific groups.
  • Work productively in a team environment and independently and deliver against timelines.

Experience and essential skills:

  • BA/BS degree in a related science;
  • 8+ years of experience in laboratory histology (embedding, cutting, immunohistochemistry, and cover- slipping);
  • Must have managed CROs and external collaborators for IHC based method development and qualification.
  • Expertise in IHC, ISH, slide scanning (Aperio AT Turbo/FL, Leica Versa), image analysis (Aperio Scan Scope AT) and related sample preparation;
  • Previous experience supporting biomarker identification and clinical assay development alongside R&D teams;
  • Demonstrated experience supporting the development of novel assays and other platforms including digital pathology, multiplexing, and immune-oncology histology assays.
  • Able to run immunohistochemistry assays independently
  • Prior experience working with immuno-oncology systems preferred.
  • Demonstrated experience in complex problem solving.
  • Excellent organizational, communication skills and a pro-active mentality.
  • Demonstrated experience functioning within a multi-disciplinary team and ability to integrate cross-functional information, to optimize work flows.