Cambridge, MA, US

Company Summary

Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. The Company utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines.  Neon Therapeutics’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute.  NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer.  Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.
In addition, Neon has established strategic partners in CRISPR, Merck, and Apexigen to harness opportunities for combination therapies.  By the end of 2018, it is anticipated there will be multiple clinical programs utilizing Neon’s platform.

Neon Therapeutics was incubated and launched by Third Rock Ventures and raised a $55M Series A in 2015 and more recently a $106M Series B in December 2017.

Position Summary

The successful candidate will work in the Neon SELECT program that aims to develop therapies against neoantigen targets shared across patients. S/he will focus on generating and studying T cell responses to shared neoantigens, with particular focus on peptide design and T cell receptor characterization. The candidate will need to work on a team but also independently test many different technologies. S/he will need to work effectively on a team while also independently perform cell and molecular biology assays. The candidate will work closely with the departments of T cell immunology, molecular immunology, peptide chemistry, and bioinformatics.

Job Responsibilities:

  • Culture and manipulation of human T cells
  • Assessment and analysis of specificity of human T cells by multicolor flow cytometry
  • Perform scRNA and TCR sequencing as well as data analysis
  • Design and analysis of immunogenic peptide sequences
  • Production of stable cell lines using transfection or transduction
  • Analysis and presentation of results to larger scientific groups
  • Assist with the training of lab personnel
  • Work productively in a team environment and independently and deliver against timelines.

Experience and essential skills:

  • M.S. with 5-8 years of experience, or Ph.D. with 0-2 years of experience in industry with a strong background in immunology.
  • A strong background in adaptive immunity in the context of cancer is preferred
  • Demonstrated mastery of flow cytometry and related data analysis
  • Experience with functional immune assays, such as cytokine analysis
  • General molecular biology techniques, including plasmid cloning and preparation
  • Experience with lentivirus preparation and infection
  • Ability to organize and tabulate data.
  • Strong evidence of leadership background and experience working in cross-functional teams
  • Excellent and record-keeping skills.
  • Strong written and oral communication skills.
  • Independent, flexible, self-motivated.