Research Associate / Senior Research Associate, Biochemistry/Biophysics at Relay Therapeutics
Cambridge, MA, US
The Relay team:
Our company was founded on the premise that protein motion can be used to build breakthrough medicines. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients’ lives.
Our extraordinary team is equal parts bright and bold, with a real passion for working in intellectually stimulating environments. We look for people who are committed to working together in a collaborative and rigorous culture.
We’ve built the kind of work environment that not only gets but keeps people excited and focused. Putting protein motion at the heart of drug discovery is a challenge, but we are confident that our team’s dedication and urgency will create opportunities that profoundly impact the lives of the patients. We're building a company for the ages. Are you ready to #jointherelay?

The opportunity

    • We are looking for a self-motivated researcher to join our Biochemistry, Biophysics and Structural Biology team. Our group brings protein motion at the center of drug discovery.  We are applying cutting edge technology towards the discovery, characterization and optimization of small molecule therapeutics towards targets representing high unmet medical needs. We are seeking a highly motivated, creative and collaborative scientist.  Are you ready to join us and discover the next generation of innovative therapeutics based on protein motion?

Your role

    • You’ll lead functional and mechanistic characterization of enzymes, substrates, multi-protein complexes
    • You will design, develop and troubleshoot diverse biochemical and biophysical assays. Your work will help enable us to assess both mechanism and small molecule modulation of cancer targets, including hit identification, validation and optimization
    • You can expect that analysis, interpretation, documentation and presentation of your data to local groups and project teams will be part of your day.
    • We’ll depend on you to assess, adopt and implement emerging technologies and experimental techniques that will enhance and enable drug discovery
    • Your voice is important.  We’ll count on you to contribute to group knowledge and expertise through collaboration and idea exchange with multidisciplinary teams

Your background

    • You earned a Bachelors or Masters degree in Biochemistry, Biophysics, Enzymology or a related field
    • You have spent at least 5 or more years gaining relevant industry experience
    • You have a solid understanding of protein function and enzyme mechanism.  You also have experience with biochemical and biophysical assay development for protein target and small molecule inhibitor characterizations as well as protein-ligand binding interactions
    • You have a basic understanding of compound management and ability to work on automated liquid handling instrumentation
    • You're an articulate, open communicator with the ability to analyze, interpret and present data in a clear manner.
    • You have an interest in contributing to medicinal chemistry drug discovery efforts to evaluate compound SAR and mode of action characterization
    • Have you dabbled with fluorescence-based assay techniques (e.g. HTRF, FP, quench assays) and label-free technologies (e.g. SPR, ITC, DSC, LC-MS)?  This is a big plus.
    • Do you have experience in second harmonic generation technique (Biodesy)?   Another plus.
At Relay, we believe that along with our scientists, our culture is our greatest asset.  In fact we're proud to share we were named as one of the Boston Business Journal's "Top Places to Work" in 2017 & 2018.  To drive that culture, we encourage each employee to bring their full selves to work every single day so they can function in a highly creative and authentic way. If this resonates with you, drop us a line.
Relay Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.