Careers

Principal Scientist/ Associate Director / Director of Medicinal Chemistry at Tango Therapeutics
Cambridge, MA, US

Job Summary

Tango, a 2017 “Fierce 15” company, is an exciting new oncology company launched by Third Rock Ventures, one of Boston’s premier biotech funding groups. Our focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We invert the traditional discovery paradigm by putting patient selection before target identification. We use deep DNA sequencing and CRISPR-based screening to identify novel targets for specific subgroups of cancer patients. Our goal is to leverage the principles of synthetic lethality to find novel weaknesses in cancer cells and use them to provide a roadmap to cures. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments; thereby enabling greater speed, success, and impact for those patients.

Tango Therapeutics is seeking a motivated and innovative chemist to lead the design and execution of medicinal chemistry programs in the discovery of novel oncology drug candidates in multiple target classes. The Chemistry Team is a collaborative, open, team-oriented group committed to working together to achieve goals.

Job Responsibilities

 

  • Drive the discovery of new molecules with an emphasis on design and interpretation of various hit-finding techniques and lead optimization strategies, including in vitro and in vivo ADME/PK, pharmacology, and toxicology
  • Lead programs through CRO partnerships across multiple companies
  • Initiate, grow, and maintain excellent relationships with scientists and managers at CROs
  • Collaborate with research groups across the organization and keep all stakeholders informed
  • Actively follow and integrate scientific advancements and literature within the area of research interest

 

Required Skills & Qualifications

 

  • PhD in Organic Chemistry and at least 7 years of relevant pharmaceutical industry experience, or BS/MS with equivalent experience
  • Demonstrated success and major contributions in successful lead optimization programs
  • In-depth knowledge of the entire drug discovery process, with expertise and demonstrated strong skills in medicinal chemistry drug design and discovery
  • Experience functioning within a strong multi-disciplinary team and utilizing physicochemical, biochemical, ADME/PK, and pharmacological data to drive medicinal chemistry strategies is required
  • Ability to apply modern and emerging methodologies and technologies to the synthesis of small molecules
  • Strong organizational and communication skills within a matrix driven organization
  • Prior experience acting as project or chemistry team lead preferred
  • Experience managing external FTE resources in chemistry to high levels of performance is favorably considered

 

Company Overview

Tango, a 2017 “Fierce 15” company, is an exciting new oncology company launched by Third Rock Ventures, one of Boston’s premier biotech funding groups. Our focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We invert the traditional discovery paradigm by putting patient selection before target identification. We use deep DNA sequencing and CRISPR-based screening to identify novel targets for specific subgroups of cancer patients. Our goal is to leverage the principles of synthetic lethality to find novel weaknesses in cancer cells and use them to provide a roadmap to cures. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments; thereby enabling greater speed, success, and impact for those patients.