Cambridge, MA, US

Company Summary

Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. Neon utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines.  Neon Therapeutics’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute.  NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer.  Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.

In addition, Neon has established strategic partnerships with CRISPR, Merck, and Apexigen, among others.  By the end of 2018, it is anticipated there will be multiple clinical programs utilizing Neon’s platform.

Neon Therapeutics was incubated and launched by Third Rock Ventures, raised a $55M Series A in 2015 and, more recently, a $106M Series B in December 2017, and has filed for an initial public offering.

Position Summary

Neon is seeking a highly-motivated Research Associate with the goal of developing a neoantigen specific T cell product to be used in adoptive T cell therapy.  As part of a multi-disciplinary team, you will work closely with biochemists, bioinformatics and the departments of peptide chemistry, molecular biology and immune monitoring to develop and assess efficacy of this approach.   This position reports to a Senior Scientist, T cell Immunology.

A successful candidate will embody and demonstrate commitment to Neon’s core values: Patients, People, Science, Tenacity, Pioneer, Integrity

Primary Responsibilities

  • Production of dendritic cells from human PBMC

  • Culturing of human T cells

  • Assessment of specificity and functionality of human T cells by multicolor flow cytometry

  • Analysis of multicolor flow cytometry data

  • Measurement of cytokines in cell culture supernatants

  • Tracking and compiling results in an electronic notebook

  • Assisting with the training of lab personnel

  • Present results to other scientific teams

Experience and Essential Skills

  • BS or MS in immunology and/or relevant experience in cancer immunology

  • A strong interest in adaptive immunity in the context of cancer

  • Mammalian cell line and/or primary cell culture experience is preferred

  • Demonstrated experience with flow cytometry and other immune related assays is preferred

  • Ability to work independently, as well as in a collaborative environment to meet project goals

  • Excellent attention to detail

  • Excellent written and oral communication skills

  • Enjoys solving challenging scientific questions in a fast pace environment

  • Independent, flexible, self-motivated, and the ability to work well with others

Core Values

At Neon Therapeutics, our core values drive our actions ever day. Successful candidates will demonstrate and embody our company’s commitment to:

  • Patients: Urgently develop life-changing medicines

  • People: Listen, Learn, Teach

  • Science: Creative, Rigorous, Uncompromising

  • Tenacity: Persevere, Build Neon to last

  • Pioneer: Leave the comfort zone, Create the future

  • Integrity: Do RIGHT

Equal Employment Opportunity

Neon Therapeutics provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, Neon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities.



Neon Therapeutics is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.