Senior Scientist / Principal Scientist, DMPK at Relay Therapeutics
Cambridge, MA, US
Our company was founded on the premise that protein motion can be used to build breakthrough medicines. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients’ lives. We don't just stare hard problems in the face. We go out looking for them. Are you energized by attempting to do the impossible? We're looking for you.
We’ve built the kind of work environment that not only gets but keeps people excited and focused. Putting protein motion at the heart of drug discovery is a challenge, but we are confident that our team’s dedication and urgency will create opportunities that deeply impact the lives of the patients. We're building a company for the ages. Are you ready to #jointherelay?

The opportunity

    • We are seeking a versatile, self-motivated person to become an integral part of the R&D teams and the Nonclinical Development function. You will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams developing small molecule modulators of clinically meaningful targets in cancer. We are looking for a consummate teammate who seeks a scientifically rigorous and collaborative environment in which to grow their career in drug R&D.
    • Expect a multi-faceted experience, as you will interact and collaborate cross-functionally with scientists in other groups, including chemists, biologists, biochemists, structural biologists, and computational chemists.

The role

    • In partnership with Nonclinical leads, you will set the DMPK strategy for Relay’s discovery programs
    • We'll look to you for the establishment and oversight of activities at CROs, including in vitro ADME, PK, bioanalysis and PK/PD modeling
    • You will be the functional area representative for DMPK on multidisciplinary project teams
    • You will design, analyze and interpret preclinical DMPK studies in support of program goals
    • You will also use a broad array of DMPK data to enable integrated analyses of biopharmaceutics, drug metabolism, PK/PD, human PK/dose projections and DDI risk
    • You'll be seen as a key member of the team driving Pharmacology efforts for Relay programs

Your background

    • You earned an advanced degree, such as your Masters and bring 7+ years of experience, or you have your Ph.D. and 3+ years of experience, with a focus in pharmacokinetics, pharmacology or related discipline.
    • You have small molecule DMPK experience - this is a must.
    • Have you spent time working specifically on oncology drug discovery? This is highly preferred.
    • You have extensive experience optimizing and characterizing the ADME properties of small molecule drug candidates, supported by a strong publication record in DMPK sciences. You also bring expertise in the interplay between DMPK parameters, physicochemical and molecular properties
    • Expertise in PK/PD modeling from discovery through early development. Proficient with Phoenix WinNonlin or similar.
    • Experience leading DMPK on projects particularly in discovery and early development
    • Operational experience and familiarity with the drug discovery and development process, including external regulatory requirements
    • You're comfortable navigating complexity and ambiguity in an environment that is constantly changing, and even thrive in this. You're poised interacting with consultants, external vendors and internal cross-functional project teams. You also have track record of achieving results in a virtual/outsourced model
    • You're an articulate, open communicator with the ability to analyze, interpret and present data in a clear manner
    • You are familiar with authoring and reviewing PK sections of regulatory dossiers
At Relay, we believe that along with our scientists, our culture is our greatest asset.  In fact we're proud to share we were named as one of the Boston Business Journal's "Top Places to Work" in 2017 & 2018.  To drive that culture, we encourage each employee to bring their full selves to work every single day so they can function in a highly creative and authentic way. If this resonates with you, drop us a line.
Relay Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.