Director Level, Development Program Manager at Fulcrum Therapeutics
Cambridge, MA, US

As the Development Program Manager, you will oversee Fulcrum’s R&D development portfolio and create the company’s global project management and resource capacity planning capability, tools, and metrics in order to enhance the efficiency and effectiveness of Fulcrum’s matrix operating model and support the company’s growth. You will partner closely with Senior Management and Portfolio Leadership to ensure comprehensive pipeline prioritization and program decision making. You will oversee broad program management for development programs and will be responsible for the hands-on management of program operations. You will work collaboratively with the program teams to manage and integrate the diverse R&D of drug development and operational activities through interactions with Research, Molecular Sciences, Translational Medicine, Clinical Operations, Finance, and Business Development, in addition to external vendors and partners. By ensuring the appropriate use of tools and metrics, you will enhance project and program delivery and information dissemination to the business; ultimately aligning program activities with corporate strategy and driving value creation and results.


  • Champion and lead Development Operations for advanced Programs with a focus on cross-functional and vendor integration
  • Develop and manage cross-functional strategies, plans, and activities from IND enabling through commercialization
  • Lead program-specific Strategic Team and Development Core Team meetings, including agenda development and prioritization and summary authoring
  • Partner closely with Functional Heads, aligned Scientific Team Lead(s), and cross-functional team members to define and track program goals and drive accountability
  • Partner with Finance and Functional Heads to provide program budget and resource oversight (reporting, planning, etc.)
  • Integrate and manage cross-functional vendors and CRO oversight
  • Maintain and coordinate cross-functional timelines, dashboards, and Gantt charts, including tracking milestones/accomplishments and identification of risks and development of associated leadership/team communications
  • Coordinate and lead authoring and maintenance of Strategic Program Plans (SPP) and Target Product Profiles (TPP)
  • Establish and oversee appropriate document management standards (Reports, submissions, technology, etc.) – QC/QA
  • Lead Alliance Management efforts (if partnered Program)
  • Oversee IP Strategy development and management
  • Plan and execute Patient Community Engagement strategies, activities, sponsorships, and relationships


  • BS/BA, Advanced degree preferred
  • 10+ years’ experience in life sciences industry, with 8+ years of demonstrated program management experience managing cross-functional product development efforts

Knowledge, Skills and Abilities

  • Demonstrated project management skills; must have high degree of energy, accuracy and attention to detail
  • Ability to thrive in a fast-paced, innovative and dynamic environment while remaining flexible, proactive, resourceful and efficient are essential
  • Ability to work independently and successfully in a matrix environment, and to prioritize and manage multiple tasks simultaneously
  • Ability to integrate and influence cross-functional issues, balance competing priorities effectively, and successfully negotiate desired outcomes
  • Excellent analytical and organizational skills (resources, timelines, cost/risk/benefit analysis)
  • Strong communication skills and fluency with project management tools (Microsoft Project, Excel, PPT presentations, writing, etc.)
  • Outstanding leadership skills and demonstrated passion for creating new medicines, including excellent verbal and written communication skills, an innovative approach to problem-solving, and an integrated view of business and scientific issues