Associate Director/Director, Program Management at Tango Therapeutics
Cambridge, MA, US

Company Overview

Tango, a 2017 “Fierce 15” company, is an exciting new oncology company launched by Third Rock Ventures, one of Boston’s premier biotech funding groups. Our focus is on exploiting synthetic lethal interactions to discover and develop new breakthrough cancer therapies.

Our discovery efforts begin and end with patients. We invert the traditional discovery paradigm by putting patient selection before target identification. We use deep DNA sequencing and CRISPR-based screening to identify novel targets for specific subgroups of cancer patients. Our goal is to leverage the principles of synthetic lethality to find novel weaknesses in cancer cells and use them to provide a roadmap to cures. As we advance our molecules into the clinic, our trials will enroll the patients most likely to benefit from our new treatments; thereby enabling greater speed, success, and impact for those patients.

Job Summary

Tango Therapeutics is seeking a Program Manager to guide our oncology drug discovery programs as we move exciting targets toward and into the clinic. This individual will be responsible for managing drug discovery programs in collaboration with program leaders (PL) across the organization. They will develop integrated drug discovery plans to drive selection of clinical candidates for oncology clinical development. Tango is a highly-collaborative organization, so the successful candidate will be comfortable working in teams and collaborating with team members of all levels.

Job Responsibilities

Responsibilities include, but are not limited to:

  • Provides operational leadership for drug discovery of small molecule cancer therapeutics through development candidate selection and, clinical Proof of Concept (POC)
  • Supports the PL in the development of the program strategy and selection of the development candidate (DC) by planning and tracking activities in lead optimization, pharmacology, toxicology and ADME studies, preclinical work for patient selection and indication expansion, drug supply and formulation development
  • Achieves organizational alignment and seamless execution of the integrated drug discovery plans by working cross functionally within Tango and with CROs
  • Coordinates the preparation of presentations for Tango’s Board of Director meetings
  • Represents, as needed, the program team to discussions with management, scientific founders and Tango directors
  • Supports the alliance manager in the preparation for Joint Steering Committee Meetings for partnered programs
  • Leads the team in the assembly of program plans and budgets. Tracks the program budget and works with department heads to ensure headcount allocations match workload for the programs
  • Tracks program progress against the plan, working with department heads to identify and resolve resource constraints consistent with corporate priorities
  • Establishes, together with the PL, program and personal goals that are aligned with corporate goals 
  • Schedules, facilitates, and documents program team and ad-hoc program meetings; ensures uniformity between programs including agendas, meeting minutes and other program documentation
  • Identifies, tracks and supports resolution efforts for all program-related issues. Relays positive and negative deviations from program plans to the program team and management
  • Facilitates resolution of conflicts between functional groups while maintaining objectivity
  • Builds team spirit and positive team environment
  • Supports VP of Portfolio Management with the preparation and conduct of the R&D Portfolio meeting


Required Skills & Qualifications


  • Doctoral in life sciences with 7+ years industry experience (or applicants with BS or MS and 12+ years in a pharmaceutical or biotech company)
  • Strong scientific background in Biology, Chemistry, or other area of drug discovery with at least 5 yrs experience with multi-functional drug discovery program teams
  • Expert knowledge of drug discovery
  • Oncology experience strongly preferred 
  • Must have the ability to motivate others, prioritize multiple tasks, and maintain positive interpersonal skills
  • Excellent written and verbal communication.  Must be able to clearly present and communicate complex program information in both formal and informal settings
  • Good conflict resolution and problem-solving skills are a must
  • Must demonstrate good leadership and team building skills
  • Computer skills including Microsoft Program and Microsoft Office are required