Senior Research Associate/Scientist, Proteomics at Neon Therapeutics
Cambridge, MA, US

Position:                       Senior Research Associate/Scientist, Proteomics
Reports to:                  Program Manager Proteomics
Location:                      Cambridge, MA

Company Summary

Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. The Company utilizes its expertise in bioinformatics, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines.  Neon Therapeutics’ lead program is NEO-PV-01, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute.  NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb, in patients with measurable metastatic melanoma, non-small cell lung cancer and bladder cancer.  Also in development are NEO-PTC-01, a bespoke autologous T cell therapy, and a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.

Neon Therapeutics was incubated and launched by Third Rock Ventures, Raised a $55M Series A in 2015, a $106M Series B in December 2017, and completed its IPO, raising $100M in the summer of 2018.

At Neon, our core values act as a guidepost for our thoughts and behaviors:

  • Patients: Urgently develop life-changing medicines
  • People: Listen/Learn/Teach
  • Science: Creative/Rigorous/Uncompromising
  • Tenacity: Persevere/Build Neon to last
  • Pioneer: Leave the comfort zone/Create the future
  • Integrity: Do RIGHT

Job responsibilities include:

  • Prepare peptide samples for LC-MS/MS analysis (desalting, SCX, fractionation)
  • Perform and optimize immunopurification and other enrichment strategies
  • Participate in cell culture and sample generation
  • Perform LC-MS/MS analyses of biologically derived protein and peptide mixtures (Thermo Instruments)
  • Analyze raw LC-MS/MS data and post-processed data
  • Contribute to the selection of the methods and controls during experimental design
  • Review scientific literature and collaborate with cross-functional teams
  • Track and compile results in an electronic notebook
  • Assists with the training of lab personnel
  • Present results to other scientific groups

Experience and essential skills:

  • PhD degree in proteomics, biology, chemistry or relevant field
  • Experienced Senior Research Associate/Budding Scientist in proteomics, biology, chemistry, or relevant field.
  • 3+ years of relevant research experience
  • Strong background in cell biology, molecular biology, virology, biotechnology, and immunology
  • Familiarity with proteomics workflows for enzymatic digestion of proteins
  • Familiarity with LC-MS/MS workflows for data acquisition including unbiased data collection and MS-based quantitative assays
  • Familiarity with data processing workflows, such as database searching programs and/or quantitative software such as Skyline
  • Familiarity with cell culture techniques and animal models
  • Experience with basic molecular biology and biochemistry techniques
  • Ability to organize and tabulate data
  • Excellent attention to detail
  • Ability to maintain inventories of equipment, supplies, and related research materials
  • Excellent record-keeping skills
  • Strong written and oral communication skills
  • Independent, flexible, self-motivated, and the ability to work well with others

Optional skills:

  • Familiarity with protocols for chemical labeling of peptide samples (iTRAQ, TMT)
  • Exposure to R or other statistical tools

Equal Employment Opportunity

Neon Therapeutics provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, or genetics. In addition to federal law requirements, Neon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities.