Scientist, Translational Medicine at Relay Therapeutics
Cambridge, MA, US
About Relay Therapeutics
Relay Therapeutics is a new breed of company at the intersection of computation and biotechnology that is committed to creating medicines that will have a transformative impact on patients.
We combine unprecedented computational power with leading-edge experimental approaches across the fields of structural biology, biophysics, chemistry, and biology. This integration illuminates – for the first time – the full mobility of a protein and provides key insights into how the dynamic nature of a protein’s conformation regulates function. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients’ lives. We don't just stare hard problems in the face. We go out looking for them. Are you energized by attempting to do the impossible? We're looking for you.
At Relay, our team is driven by the ultimate collaboration across each of our drug discovery disciplines. Putting protein motion at the heart of drug discovery is a challenge, but we are confident that our team’s dedication and urgency will create opportunities that deeply impact the lives of the patients.  Our initial programs are focused on developing therapeutics in oncology.
Relay Therapeutics is a private company launched in 2016 with financing from Third Rock Ventures and an affiliate of D. E. Shaw Research. To date the company has raised $520M from investors including Third Rock Ventures, SoftBank Vision Fund, GV, Casdin Capital, BVF Partners, EcoR1 Capital, Foresite Capital, Perceptive Advisors, Tavistock Group and an affiliate of D.E. Shaw Research.

The Opportunity

    • In this newly created role, you will work collaboratively with the biology and clinical operations teams to ensure successful planning and execution of translational medicine objectives in oncology clinical development.   You will own implementation of the biomarker strategy in early clinical trials, from ensuring assays are fit-for-purpose through data analysis and reporting.   Your efforts will have a high impact, being critical for successfully bringing novel targeted cancer therapeutics to the specific patients that need them.  

Your Role

    • You will work with the Biology lead to operationalize the biomarker strategy, including the prospective enrollment of genetically defined cancer patient populations and assessment of pharmacodynamic endpoints 
    • You will be responsible for the assessment of biomarker assays as analytically validated and fit for the intended purpose
    •  You will identify the appropriate CRO / external partner to run biomarker assays, once validated.   You will maintain and effectively manage relationships with CROs / external partners.     
    • You will author appropriate sections of documents, including laboratory manuals, translational sections of clinical protocols, clinical study reports, etc.   
    • You will collaborate with the clinical operations team to ensure execution of biomarker assays in clinical protocols including specimen acquisition, handling, processing, analysis, and dissemination of results 
    • You will communicate with investigators and participating sites to ensure scientific engagement and appropriate execution

Your Background

    • You have earned a PhD with 5+ years of experience in clinical biomarker development and translational science in oncology.   BS/MS level scientists with significant experience will also be considered 
    • You have a background in molecular/cellular biology or genomics in oncology 
    • You have experience in the validation and implementation of clinical biomarkers: identification of the most appropriate platforms for mutation detection; clinical evaluation of other molecular biomarkers; evaluation and selection of appropriate CROs/ external labs to run biomarker assays; identification of appropriate specimen collection protocols; oversight of sample logistics and handling 
    • You have experience authoring laboratory manuals and appropriate sections of clinical documents 
    • You have a track record of successful execution of clinical biomarker activities demonstrated by abstracts, peer-reviewed publications and/or patents 
    • You’re known as an articulate, open communicator.  You can flex to different work styles and believe that the best outcomes result from leveraging the strengths of your team members.   
    • You are a collaborative, results-oriented individual who enjoys working on high impact work
At Relay, we believe that along with our people, our culture is our greatest asset.  In fact we're proud to share we were named as one of the Boston Business Journal's "Best Places to Work" in 2017, the #1 place for small companies in 2018 & the #2 place for small companies in 2019. To drive that culture, no one will stop you or hold you back. Instead, we will give you the tools and colleagues to push forward relentlessly and cheer you on as you go. If this resonates with you, drop us a line.
We believe in building balanced teams and a place where our people can be their full self every day. We encourage people from underrepresented backgrounds to apply.